Antifungal Activity of Dihydrobenzofuran Neolignans

ثبت نشده
چکیده

Submit Manuscript | http://medcraveonline.com Superficial fungal infections of the skin, hair, and nails are dermatomycoses that affect the individuals’ health quality of life and are considered a public health issue [1-3]. Dermatological infections affect more than 25% of the people worldwide living in tropical and subtropical regions, mainly individuals involved in outdoor activities, such as agriculture, lumbering, and hunting, among others [4-6]. The responsible for the dermatomycoses is pointed out as dermatophytes, non-dermatophytic filamentous and yeasts forms of fungi, but in most of the cases, the etiologic agents are the dermatophytes [7]. Furthermore, the species causative of dermatomycoses demonstrate considerable variation depending on the geographical location, economic situations as well as population migrations and weather conditions, and can affect the treatment of such fungal infections [1,6,8].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dihydrobenzofuran Neolignans Isolated from Euonymus alatus Leaves and Twigs Attenuated Inflammatory Responses in the Activated RAW264.7 Macrophage Cells

− Anti-inflammatory effects of dihydrobenzofuran neolignans isolated from Euonymus alatus leaves and twigs were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Six neolignans, (+)simulanol (1), (+)-dehydrodiconiferyl alcohol (2), (−)-simulanol (3), (−)-dehydrodiconiferyl alcohol (4), (+)dihydrodehyrodiconiferyl alcohol (5), threo-buddlenol B (6) effectively inhibited...

متن کامل

Study of the Cytotoxic and Antifungal Activities of Neolignans 8.O.4 ́ and Structurally Related Compounds

In the present work we report the antifungal and cytotoxic activities of a neolignan 8.O.4 ́series. The most active antifungal compounds show a significant cytotoxic effect which might be related. Introduction Fungal infections have emerged during the past two decades as important pathogens causing morbidity and mortality in an increasingly diverse and progressively expanding populations of inmu...

متن کامل

Enantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations

Eight pairs of enantiomeric neolignans, norlignans, and sesquineolignans (1a/1b-8a/8b), together with five known neolignans (9a/9b and 10-12), have been isolated from 70% acetone extract of the whole plants of Phyllanthus glaucus Wall. (Euphorbiaceae). The racemic or partial racemic mixtures were successfully separated by chiral HPLC using different types of chiral columns with various mobile p...

متن کامل

4-Hydroxy-7-methyl-3-phenylcoumarin Suppresses Aflatoxin Biosynthesis via Downregulation of aflK Expressing Versicolorin B Synthase in Aspergillus flavus.

Naturally occurring coumarins possess antibacterial and antifungal properties. In this study, these natural and synthetic coumarins were used to evaluate their antifungal activities against Aspergillus flavus, which produces aflatoxins. In addition to control antifungal activities, antiaflatoxigenic properties were also determined using a high-performance liquid chromatography in conjunction wi...

متن کامل

Asperfuran, a novel antifungal metabolite from Aspergillus oryzae.

Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017